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Journal of Clinical Microbiology, November 2003, p. 5277-5281, Vol. 41, No. 11
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.11.5277-5281.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Association of Cytolethal Distending Toxin Locus cdtB with Enteropathogenic Escherichia coli Isolated from Patients with Acute Diarrhea in Calcutta, India

Mritunjay Pandey,1 Asis Khan,1 Suresh C. Das,2 Bhaswati Sarkar,1 Soumen Kahali,1 Subhra Chakraborty,1 Santanu Chattopadhyay,1 Shinji Yamasaki,3 Yoshifumi Takeda,4 G. Balakrish Nair,5 and T. Ramamurthy1*

National Institute of Cholera and Enteric Diseases,1 Eastern Regional Station, Indian Veterinary Research Institute, Calcutta, India,2 Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Osaka,3 Jissen Women's College, Tokyo, Japan,4 International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh5

Received 19 February 2003/ Returned for modification 5 June 2003/ Accepted 20 August 2003

Among Escherichia coli strains isolated from stool specimens from patients with acute diarrhea, 1.4% were found to harbor cdtB by use of enrichment cytolethal distending toxin (CDT) PCR. These isolates were identified as being enteropathogenic E. coli (EPEC). In a retrospective study using a probe hybridization assay, 6 of 138 EPEC strains were found to harbor the cdtB locus. cdtB-positive isolates mostly belong to the O86a and O127a serogroups, with the former being associated with higher expression of CDT. Pulsed-field gel electrophoresis profiles showed that the EPEC strains harboring cdtB strains are genetically diverse.

* Corresponding author. Mailing address: National Institute of Cholera and Enteric Diseases, P-33, CIT Rd., Scheme-XM, Beliaghata, Calcutta 700 010, India. Phone: 91-33-350-0448/1176, ext. 157. Fax: 91-33-350-5066. E-mail: tramu{at}vsnl.net.

Journal of Clinical Microbiology, November 2003, p. 5277-5281, Vol. 41, No. 11
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.11.5277-5281.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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