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Journal of Clinical Microbiology, November 2003, p. 5302-5307, Vol. 41, No. 11
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.11.5302-5307.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Invasive Mycotic Infections Caused by Chaetomium perlucidum, a New Agent of Cerebral Phaeohyphomycosis

M. A. Barron,1* D. A. Sutton,2 R. Veve,3 J. Guarro,4 M. Rinaldi,2,5 E. Thompson,2 P. J. Cagnoni,6 K. Moultney,7 and N. E. Madinger1,7

Division of Infectious Diseases,1 Bone Marrow Transplant Program, Department of Medicine,6 Department of Pathology, University of Colorado Health Sciences Center, and,3 Clinical Microbiology Laboratory, University of Colorado Hospital, Denver, Colorado 80262,7 Department of Pathology, University of Texas Health Sciences Center at San Antonio,2 Laboratory Service, Audie L. Murphy Division, South Texas Veterans Health Care System, San Antonio, Texas 78229,5 and Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira I Virgili, 43201 Reus, Tarragona, Spain4

Received 21 March 2003/ Returned for modification 9 May 2003/ Accepted 26 June 2003

We report the first two cases of invasive human mycoses caused by the phaeoid ascomycete, Chaetomium perlucidum, and review the English literature regarding invasive Chaetomium infections. Fatal disseminated disease involving the brain, heart, lungs, and spleen is described in an acute myelogenous leukemia patient. A second patient with a history of asthma and chronic bronchiectasis experiencing right-middle-lobe syndrome grew C. perlucidum from lung tissue. This study adds C. perlucidum to the list of other known neurotropic Chaetomium species, C. atrobrunneum and C. strumarium, and also documents this organism's ability to disseminate beyond the central nervous system.

* Corresponding author. Mailing address: University of Colorado Health Sciences Center, Division of Infectious Diseases, 4200 E. Ninth Ave., Box B168, Denver, CO 80262. Phone: (303) 315-1113. Fax: (303) 315-8681. E-mail: michelle.barron{at}uchsc.edu.

Journal of Clinical Microbiology, November 2003, p. 5302-5307, Vol. 41, No. 11
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.11.5302-5307.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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