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Journal of Clinical Microbiology, December 2003, p. 5729-5731, Vol. 41, No. 12
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.12.5729-5731.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Caspofungin Activity against Clinical Isolates of Fluconazole-Resistant Candida

Departments of Pathology,¹ Epidemiology,² Medicine, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa³

Received 10 June 2003/ Returned for modification 14 August 2003/ Accepted 1 September 2003

A total of 7,837 clinical isolates of Candida were tested against fluconazole, and 351 resistant (fluconazole MIC 64 µg/ml) isolates were identified (4% of the total tested). All fluconazole-resistant isolates were inhibited by caspofungin at concentrations that can be exceeded by standard doses (MIC at which 90% of the isolates were inhibited, 1 µg/ml; 99% of the MICs were 2 µg/ml).

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