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Journal of Clinical Microbiology, December 2003, p. 5770-5773, Vol. 41, No. 12
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.12.5770-5773.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Cocirculation and Evolution of Two Lineages of Influenza B Viruses in Europe and Israel in the 2001-2002 Season

X. Sherry Chi, Trentice V. Bolar, Ping Zhao, Ruth Rappaport, and Sheau-Mei Cheng*

Clinical Immunology and Virology Department, Applied Immunology and Microbiology Division, Wyeth Vaccine Research, Pearl River, New York 10965

Received 18 July 2003/ Returned for modification 22 August 2003/ Accepted 11 September 2003

Forty-nine influenza B virus isolates collected in Belgium, Finland, Spain, and Israel during the 2001-2002 winter season were categorized into either of two lineages, B/Yamagata/16/88 or B/Victoria/2/87, based on the phylogenetic studies of HA1 sequences. The data trace the geographic spread of B/Victoria/2/87-like viruses and support the emergence of B/Hong Kong/1351/02-like viruses, possibly due to selective advantages of reassortment.

* Corresponding author. Mailing address: Wyeth Vaccine Research, 401 N. Middletown Rd., Bldg. 180, Pearl River, NY 10965. Phone: (845) 602-5115. Fax: (845) 602-5296. E-mail: chengsm{at}wyeth.com.

Journal of Clinical Microbiology, December 2003, p. 5770-5773, Vol. 41, No. 12
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.12.5770-5773.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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