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Journal of Clinical Microbiology, December 2003, p. 5798-5802, Vol. 41, No. 12
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.12.5798-5802.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Extraintestinal Pathogenic Escherichia coli as a Cause of Invasive Nonurinary Infections

James R. Johnson,1,2* Abby Gajewski,1,2 Alan J. Lesse,3,4,5,6 and Thomas A. Russo3,4,5,6,7

Mucosal and Vaccine Research Center, VA Medical Center,1 Department of Medicine, University of Minnesota, Minneapolis, Minnesota,2 VA Medical Center,3 Departments of Medicine,4 Pharmacology and Toxicology,5 Microbiology,6 The Witebsky Center for Microbial Pathogenesis and Immunology, University of Buffalo, Buffalo, New York7

Received 6 June 2003/ Returned for modification 11 July 2003/ Accepted 20 September 2003

Multiple Escherichia coli isolates from four adults with extraintestinal infections underwent molecular phylotyping and virulence profiling. A patient with secondary peritonitis had two low-virulence E. coli strains from phylogenetic groups A and D. In contrast, three patients with invasive extraurinary infections (septic arthritis/pyomyositis, nontraumatic meningitis/hematogenous osteomyelitis, and pneumonia) each had a single high-virulence phylogenetic group B2 strain resembling typical isolates causing urinary infection and/or sepsis, i.e., extraintestinal pathogenic E. coli.

* Corresponding author. Mailing address: Infectious Diseases (111F), Room 3B-101, VA Medical Center, One Veterans Dr., Minneapolis, MN 55417. Phone: (612) 467-4185. Fax: (612) 727-5995. E-mail: johns007{at}umn.edu.

Journal of Clinical Microbiology, December 2003, p. 5798-5802, Vol. 41, No. 12
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.12.5798-5802.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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