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Journal of Clinical Microbiology, February 2003, p. 645-650, Vol. 41, No. 2
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.2.645-650.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Bartonella Strains from Ground Squirrels Are Identical to Bartonella washoensis Isolated from a Human Patient

Michael Kosoy,1* Mike Murray,2 Robert D. Gilmore, Jr.,1 Ying Bai,1,3 and Kenneth L. Gage1

Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado,1 Washoe County District Health Department, Environmental Health Services-Vector Borne Diseases Program, Reno, Nevada,2 Yunnan Institute of Epidemic Disease Control and Research, Dali City, Yunnan, People's Republic of China3

Received 22 April 2002/ Returned for modification 2 September 2002/ Accepted 13 October 2002

The most likely animal source of a human case of cardiac disease in Washoe County, Nev., was identified by comparison of DNA sequences of three genes (citrate synthase gltA, 60-kDa heat shock protein gene groEL, and 16S rRNA gene) of Bartonella washoensis cultured from the human patient in question and of Bartonella isolates obtained from the following Nevada rodents: Peromyscus maniculatus (17 isolates), Tamias minimus (11 isolates), Spermophilus lateralis (3 isolates), and Spermophilus beecheyi (7 isolates). Sequence analyses of gltA amplicons obtained from Bartonella from the rodents demonstrated considerable heterogeneity and resulted in the identification of 16 genetic variants that were clustered within three groups in phylogenetic analysis. Each of the three groups was associated with a rodent genus, Peromyscus, Tamias, or Spermophilus. The gltA, 16S rRNA gene, and groEL sequences of a Bartonella isolate obtained from a California ground squirrel (S. beecheyi) were completely identical to homologous sequences of B. washoensis, strongly suggesting that these animals were the source of infection in the human case.

* Corresponding author. Mailing address: Centers for Disease Control and Prevention, NCID/DVBID, P.O. Box 2087, Rampart Rd., Fort Collins, CO 80522. Phone: (970) 266-3522. Fax: (970) 221-6476. E-mail: mkosoy{at}cdc.gov.

Journal of Clinical Microbiology, February 2003, p. 645-650, Vol. 41, No. 2
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.2.645-650.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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