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Journal of Clinical Microbiology, February 2003, p. 816-818, Vol. 41, No. 2
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.2.816-818.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Rapid Detection of Rifampin Resistance in Mycobacterium tuberculosis Isolates by Heteroduplex Analysis and Determination of Rifamycin Cross-Resistance in Rifampin-Resistant Isolates

Zeynep Saribas,* Tanil Kocagöz, Alpaslan Alp, and Ayfer Günalp

Department of Microbiology and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey

Received 15 July 2002/ Returned for modification 6 October 2002/ Accepted 22 November 2002

Direct heteroduplex analysis and a universal heteroduplex generator assay were performed to detect rifampin resistance rapidly in Turkish Mycobacterium tuberculosis isolates. Cross-resistance to rifapentine, rifabutin, and rifalazil was investigated. A relationship between specific mutations and resistance patterns, which can guide the choice of an appropriate therapeutic regimen for tuberculosis patients, was identified.

* Corresponding author. Mailing address: Department of Microbiology and Clinical Microbiology, Hacettepe University Faculty of Medicine, 06100 Sihhiye, Ankara, Turkey. Phone: 90-312-305-1560. Fax: 90-312-311-5250. E-mail: zsaribas{at}superonline.com.

Journal of Clinical Microbiology, February 2003, p. 816-818, Vol. 41, No. 2
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.2.816-818.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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