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Journal of Clinical Microbiology, February 2003, p. 838-840, Vol. 41, No. 2
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.2.838-840.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Clinical Utility of Urinary Antigen Detection for Diagnosis of Community-Acquired, Travel-Associated, and Nosocomial Legionnaires' Disease

Institut Medizinische Mikrobiologie und Hygiene, Medizinische Fakultät TU Dresden, Dresden, Germany,¹ Department of Respiratory Infections, Meningitis and STIs, Statens Serum Institut, Copenhagen, Denmark,² Karolinska Hospital, Stockholm, Sweden,³ Bundesstaatliche Baktiologisch-serologische Untersuchungsanstalt, Vienna, Austria,⁴ Scottish Legionella Reference Laboratory, Stobhill Hospital, Glasgow, Scotland,⁵ Istituto Cantonale Batteriologico, Lugano, Switzerland,⁶ Respiratory and Systemic Infection Laboratory, PHLS Central Public Health Laboratory, London, United Kingdom⁷

Received 29 July 2002/ Accepted 17 November 2002

The clinical utility of Legionella urinary antigen assays for the diagnosis of Legionnaires' disease was assessed by using samples from 317 culture-proven cases. The sensitivities of the Binax enzyme immunoassay (EIA) and Biotest EIA were found to be 93.7 and 94.4% for travel-associated infection and 86.5 and 76.0% for community-acquired infection but only 44.2 and 45.7% for nosocomially acquired infection, respectively.

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