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Journal of Clinical Microbiology, March 2003, p. 1307-1310, Vol. 41, No. 3
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.3.1307-1310.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

emm Gene Distribution among Erythromycin-Resistant and -Susceptible Italian Isolates of Streptococcus pyogenes

Claudia Zampaloni, Paola Cappelletti, Manuela Prenna, Luca Agostino Vitali, and Sandro Ripa*

Department of Molecular Cellular Animal Biology, University of Camerino, 62032 Camerino, Italy

Received 9 September 2002/ Returned for modification 18 October 2002/ Accepted 8 December 2002

The phenotypes and genetic determinants for macrolide resistance were determined for 167 erythromycin-resistant Streptococcus pyogenes strains. A cMLS phenotype was shown in 18% of the erythromycin-resistant strains, while inducible resistance was apparent in 31% and the M phenotype was apparent in 50%. The emm gene type of this set of resistant isolates and that of 48 erythromycin-sensitive isolates were determined. emm2 and emm48 were recorded only in the resistant strains of the M phenotype, while approximately all of the strains harboring the emm22 gene had the cMLS phenotype. More than 80% of the emm89-positive strains had the iMLS phenotype, and the same portion of emm4 strains presented the M phenotype. emm3 is recorded only among sensitive strains. The distribution of frequencies of the genetic determinant for the virulence factor M protein was significantly different both among organisms of different types of resistance and between resistant and sensitive populations of S. pyogenes under study.

* Corresponding author. Mailing address: Department of Molecular Cellular Animal Biology, University of Camerino, 62032 Camerino (MC), Italy. Phone: 39-0737-403241. Fax: 39-0737-636216. E-mail: sandro.ripa{at}unicam.it.

Journal of Clinical Microbiology, March 2003, p. 1307-1310, Vol. 41, No. 3
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.3.1307-1310.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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