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Journal of Clinical Microbiology, March 2003, p. 1322-1325, Vol. 41, No. 3
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.3.1322-1325.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Prospective Clinical Evaluation of the Serologic Tuberculous Glycolipid Test in Combination with the Nucleic Acid Amplification Test

Ryoji Maekura,1* Hiroaki Kohno,2 Atsushi Hirotani,1 Yoshinari Okuda,1 Masami Ito,1 Takeshi Ogura,1 and Ikuya Yano3

Toneyama National Hospital, Osaka,1 Fuji Research Laboratories, Kyowa Medex Co., Ltd., Shizuoka ,2 Department of Bacteriology, Osaka City University Medical School, Osaka, Japan3

Received 22 March 2002/ Returned for modification 12 October 2002/ Accepted 18 December 2002

We have conducted a prospective controlled multicenter study to evaluate differences in the levels of clinical utility of the tuberculous glycolipid (TBGL) serodiagnostic test and the nucleic acid amplification test in patients with smear-negative active pulmonary tuberculosis (TB). The TBGL test and the PCR test were individually not so useful for the rapid diagnosis of smear-negative active pulmonary TB. However, clinical utility was considerably improved by using the TBGL test and the PCR test in combination, especially in patients with smear-negative and culture-negative active pulmonary TB and in patients with minimally advanced lesions.

* Corresponding author. Mailing address: Toneyama National Hospital, 5-1-1, Toneyama Toyonaka-city, Osaka 560-0045, Japan. Phone: 81-6-6853-2001. Fax: 81-6-6850-1750. E-mail: maekurar{at}toneyama.hosp.go.jp.

Journal of Clinical Microbiology, March 2003, p. 1322-1325, Vol. 41, No. 3
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.3.1322-1325.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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