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Journal of Clinical Microbiology, April 2003, p. 1769-1771, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1769-1771.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Clonal Dissemination of Yersinia enterocolitica Strains with Various Susceptibilities to Nalidixic Acid

Servei de Microbiologia, Institut Clínic Infeccions i Immunología, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona,¹ C. E. Argüelles Microbiology Laboratory, Hospital Universitario Puerta de Hierro, 28008 Madrid, Spain²

Received 13 September 2002/ Returned for modification 18 October 2002/ Accepted 7 January 2003

Ten epidemiologically related Yersinia enterocolitica clinical isolates were studied. Six isolates were nalidixic acid resistant (MIC > 512 µg/ml), with mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene, suggesting clonal dissemination of a nalidixic acid-susceptible Y. enterocolitica strain which has acquired different mutations generating resistance to nalidixic acid.

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