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Journal of Clinical Microbiology, April 2003, p. 1788-1790, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1788-1790.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Occurrence of False Positives during Testing for Antibodies to Hepatitis C Virus among Volunteer Blood Donors in India

Sukanya Raghuraman,1 Thenmozhi Subramaniam,1 Dolly Daniel,2 Gopalan Sridharan,1 and Priya Abraham1*

Department of Clinical Virology,1 the Blood Bank, Christian Medical College, Vellore 632 004, Tamil Nadu, India2

Received 4 December 2001/ Returned for modification 4 August 2002/ Accepted 3 November 2002

The hepatitis C virus antibody statuses of only 11 (21.5%) of 51 initially reactive samples from volunteer blood donors could be confirmed by using additional screening and confirmatory assays; 23 (45%) were negative by all subsequent assays. Seventeen samples (33.3%) gave variable results in the different assays. The core and NS5 antigens were most immunogenic. An algorithm for serological screening of volunteer blood donors in blood banks of developing countries is suggested.

* Corresponding author. Mailing address: Department of Clinical Virology, Christian Medical College, Vellore 632 004, Tamil Nadu, India. Phone: 91-416-2222102, ext. 2616/2772. Fax: 91-416-2232035. E-mail: apriya_98{at}yahoo.com.

Journal of Clinical Microbiology, April 2003, p. 1788-1790, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1788-1790.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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