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Journal of Clinical Microbiology, April 2003, p. 1794-1797, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1794-1797.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

drs (Distantly Related sic) Gene Polymorphisms among emm12-Type Streptococcus pyogenes Isolates

Claudia M. Brandt,1* Gerhard Haase,1 Barbara Spellerberg,2 Regina Holland,1 and Rudolf Lütticken1

Institute of Medical Microbiology and National Reference Center for Streptococci, University Hospital Aachen, 52057 Aachen,1 Department of Medical Microbiology and Hygiene, University of Ulm, 89081 Ulm, Germany2

Received 6 September 2002/ Returned for modification 27 October 2002/ Accepted 7 January 2003

Twenty-eight emm12-type Streptococcus pyogenes isolates from patients with invasive and noninvasive infections or from asymptomatic carriers were genetically typed. Sequencing of drs (distantly related sic [streptococcal inhibitor of complement]) genes identified two novel alleles and revealed a polymorphism for drs similar to that of sic. No association was observed between the five different drs alleles and the five restriction patterns of the vir regulon for the isolates studied. These data suggest that drs sequencing may be useful for further differentiation of S. pyogenes isolates with emm12 and identical vir regulon restriction patterns.

* Corresponding author. Present address: Institute of Medical Microbiology, Johann Wolfgang Goethe University, Paul-Ehrlich-Strasse 40, 60596 Frankfurt am Main, Germany. Phone: 69-6301-5045. Fax: 69-6301-5767. E-mail: claudia.brandt{at}em.uni-frankfurt.de.

Journal of Clinical Microbiology, April 2003, p. 1794-1797, Vol. 41, No. 4
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.4.1794-1797.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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