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Journal of Clinical Microbiology, May 2003, p. 2084-2087, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2084-2087.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Evaluation of a New Serotyping Assay for Detection of Anti-Hepatitis C Virus Type-Specific Antibodies in Serum Samples

Elyanne Gault,1* Patrick Soussan,1,{dagger} Yoann Morice,1 Lara Sanders,2 Assia Berrada,1 Brian Rogers,2 and Paul Deny1

Laboratoire de Bactériologie-Virologie-Hygiène, Hôpital Avicenne, Assistance Publique—Hôpitaux de Paris, EA3406 ATHSCO, UFR Santé, Médecine, Biologie Humaine, Université Paris 13, 93009 Bobigny cedex, France,1 Abbott Murex, Dartford DA15LR, United Kingdom2

Received 1 November 2002/ Returned for modification 8 December 2002/ Accepted 9 February 2003

The performance of a new version (HC03) of the hepatitis C virus (HCV) serotyping 1-6 assay (Abbott Murex Laboratories), a specific test for serological determination of HCV types, was evaluated using a selected panel of 180 HCV RNA-positive sera. HC03 was more sensitive than the current HC02 version, typing 53 (37.6%) of 141 samples which were not typable with HC02. Furthermore, the HC03 specificity was 94.1% as evaluated with a panel of 22 genotyped samples. This new version of the test improves the quality of the serological approach to HCV type determination.

* Corresponding author. Mailing address: Laboratoire Virologie—Hôpital Avicenne, 125 route de Stalingrad, 93009 Bobigny Cedex, France. Phone: 33 1 48 95 56 11. Fax: 33 1 48 95 59 11. E-mail: elyanne.gault{at}avc.ap-hop-paris.fr.

{dagger} Present address: Laboratoire de Microbiologie-Hygiène, Hôpital Ambroise-Paré, UFR Paris lle-de-France Ouest, 92100 Boulogne, France.

Journal of Clinical Microbiology, May 2003, p. 2084-2087, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2084-2087.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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