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Journal of Clinical Microbiology, May 2003, p. 2161-2163, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2161-2163.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Usefulness of Urinary Antigen Detection by an Immunochromatographic Test for Diagnosis of Pneumococcal Pneumonia in Children

J. Domínguez,1* S. Blanco,1 C. Rodrigo,2 M. Azuara,2 N. Galí,1 A. Mainou,2 A. Esteve,3 A. Castellví,4 C. Prat,1 L. Matas,1 and V. Ausina1

Servei de Microbiologia,1 Servei de Pediatria,2 Centre d'Estudis Epidemiològics sobre la SIDA de Catalunya (CEESCAT),3 Servei de Cirurgia Pediàtrica, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona, Spain4

Received 10 September 2002/ Returned for modification 13 November 2002/ Accepted 14 February 2003

We evaluated an immunochromatographic assay detecting pneumococcal antigen in urine samples from children diagnosed with pneumococcal pneumonia. The sensitivity and specificity of the immunochromatographic test with nonconcentrated urine (NCU) were 86.7 and 62.9%, respectively; with concentrated urine (CU), they were 100 and 11.7%, respectively. Pneumococcal antigen was also detected in 42.5% of NCU and 87.1% of CU samples from nasopharyngeal carriers. This is a nonspecific test for the diagnosis of pneumococcal pneumonia in children, particularly the very young.

* Corresponding author. Mailing address: Servei de Microbiologia, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916 Badalona, Barcelona, Spain. Phone: 34 93 497 88 94. Fax: 34 93 497 88 95. E-mail: jadoming{at}ns.hugtip.scs.es.

Journal of Clinical Microbiology, May 2003, p. 2161-2163, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2161-2163.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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