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Journal of Clinical Microbiology, May 2003, p. 2164-2165, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2164-2165.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Frequency of Amantadine-Resistant Influenza A Viruses during Two Seasons Featuring Cocirculation of H1N1 and H3N2

Reiko Saito,1* Takatsugu Sakai,1 Isamu Sato,2 Yasuko Sano,3 Hitoshi Oshitani,1 Mizuho Sato,1 and Hiroshi Suzuki1

Department of Public Health, Graduate School of Medical and Dental Sciences,1 Yoiko Pediatric Clinic,2 Sano Clinic, Niigata City, Niigata Prefecture 951-8510, Japan3

Received 3 September 2002/ Returned for modification 21 December 2002/ Accepted 9 February 2003

In two influenza seasons during which H1N1 and H3N2 cocirculated, resistance was more frequent in H3N2 strains than in H1N1 strains after amantadine treatment. Predominant amino acid substitutions in M2 protein occurred at position 31 (serine to asparagine) in H3N2 strains and at position 27 (valine to alanine) in H1N1 strains.

* Corresponding author. Mailing address: Department of Public Health, Niigata University, Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-Dori, Niigata City, Niigata Prefecture, 951-8510, Japan. Phone: 81-25-227-2129. Fax: 81-25-227-0765. E-mail: jasmine{at}med.niigata-u.ac.jp.

Journal of Clinical Microbiology, May 2003, p. 2164-2165, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2164-2165.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2003 by the American Society for Microbiology. All rights reserved.