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Detection of Circulating Aspergillus fumigatus Galactomannan: Value and Limits of the Platelia Test for Diagnosing Invasive Aspergillosis

Service de Parasitologie-Mycologie,¹ Département de Cancérologie,² Département de Médecine Aïgue Spécialisée, Centre Hospitalier Universitaire, 38043 Grenoble, France³

Received 5 August 2002/ Returned for modification 3 September 2002/ Accepted 1 February 2003

The effectiveness of galactomannan detection with the Platelia test was evaluated in a prospective study of 3,327 sera from 807 patients. The specificity was 99.6% (748 of 751 cases). For the groups of patients with proven and probable invasive aspergillosis, the sensitivity was 50.0% (17 of 34 cases). The disappointing sensitivity associated with the presence of rare false-positive cases underlines the limits of this test.

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