This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McDonald, L. C. Articles by Snyder, J. Search for Related Content PubMed PubMed Citation Articles by McDonald, L. C. Articles by Snyder, J.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, May 2003, p. 2258-2260, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2258-2260.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Peripartum Transmission of Penicillin-Resistant Streptococcus pneumoniae

Departments of Internal Medicine,¹ Pediatrics,² Pathology, University of Louisville, Louisville, Kentucky³

Received 22 July 2002/ Returned for modification 8 October 2002/ Accepted 10 December 2002

Streptococcus pneumoniae is a rarely recognized cause of neonatal sepsis. We present a recent case of S. pneumoniae bacteremia acquired on the first day of life in a neonate born at 30 weeks of gestation to a mother without prenatal care who had prolonged rupture of the membranes and received intravenous ampicillin prior to delivery. The isolate was resistant to penicillin, with a MIC of the drug of 4 µg/ml. The child responded to a 7-day course of intravenous vancomycin. S. pneumoniae was recovered from the vagina of the mother on a swab culture collected prior to delivery, and isolates from mother and child were confirmed to be identical on the basis of pulsed-field gel electrophoresis. Although neonatal sepsis due to the peripartum transmission of S. pneumoniae is rare, this case highlights the concern that increasing efforts to prevent group B streptococcus neonatal disease may lead to an increase in neonatal infections due to resistant organisms.

This article has been cited by other articles:

• Rose, L. H., Guzman-Cottrill, J. (2006). Index of Suspicion in the Nursery. NeoReviews 7: e546-e548 [Full Text]  
• Poehling, K. A., Talbot, T. R., Griffin, M. R., Craig, A. S., Whitney, C. G., Zell, E., Lexau, C. A., Thomas, A. R., Harrison, L. H., Reingold, A. L., Hadler, J. L., Farley, M. M., Anderson, B. J., Schaffner, W. (2006). Invasive Pneumococcal Disease Among Infants Before and After Introduction of Pneumococcal Conjugate Vaccine. JAMA 295: 1668-1674 [Abstract] [Full Text]  
• Sakran, W., Valinsky, L., Koren, A., Bor, N., Yishai, R., Colodner, R. (2004). Early Onset of Neonatal Streptococcus pneumoniae Bacteremia and Septic Arthritis. CLIN PEDIATR 43: 579-581