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Journal of Clinical Microbiology, May 2003, p. 2258-2260, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2258-2260.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Peripartum Transmission of Penicillin-Resistant Streptococcus pneumoniae

L. Clifford McDonald,1* Kris Bryant,2 and James Snyder3

Departments of Internal Medicine,1 Pediatrics,2 Pathology, University of Louisville, Louisville, Kentucky3

Received 22 July 2002/ Returned for modification 8 October 2002/ Accepted 10 December 2002

Streptococcus pneumoniae is a rarely recognized cause of neonatal sepsis. We present a recent case of S. pneumoniae bacteremia acquired on the first day of life in a neonate born at 30 weeks of gestation to a mother without prenatal care who had prolonged rupture of the membranes and received intravenous ampicillin prior to delivery. The isolate was resistant to penicillin, with a MIC of the drug of 4 µg/ml. The child responded to a 7-day course of intravenous vancomycin. S. pneumoniae was recovered from the vagina of the mother on a swab culture collected prior to delivery, and isolates from mother and child were confirmed to be identical on the basis of pulsed-field gel electrophoresis. Although neonatal sepsis due to the peripartum transmission of S. pneumoniae is rare, this case highlights the concern that increasing efforts to prevent group B streptococcus neonatal disease may lead to an increase in neonatal infections due to resistant organisms.

* Corresponding author. Mailing address: Centers for Disease Control and Prevention, 1600 Clifton Rd., MS A35, Atlanta, GA 30333. Phone: (404) 639-3833. Fax: (404) 639-2647. E-mail: LJM3{at}CDC.GOV.

Journal of Clinical Microbiology, May 2003, p. 2258-2260, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2258-2260.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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