This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nulens, E.
Right arrow Articles by Verweij, P. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nulens, E.
Right arrow Articles by Verweij, P. E.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, May 2003, p. 2261-2264, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2261-2264.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Keratitis Caused by Scedosporium apiospermum Successfully Treated with a Cornea Transplant and Voriconazole

Eric Nulens,1,2* Cathrien Eggink,3 Antonius J. M. M. Rijs,1,2 Pieter Wesseling,4 and Paul E. Verweij1,2

Departments of Medical Microbiology,1 Ophthalmology,3 Pathology, University Medical Center Nijmegen,4 Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands2

Received 23 October 2002/ Returned for modification 4 January 2003/ Accepted 19 February 2003

A case of Scedosporium apiospermum keratitis was successfully treated with oral voriconazole and penetrating keratoplasty. Voriconazole levels in the aqueous humor were 53% of the levels in plasma and exceeded the MIC for the isolate by sevenfold.

* Corresponding author. Mailing address: Department of Medical Microbiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31 24 3614356. Fax: 31 24 3540216. E-mail: e.nulens{at}mmb.umcn.nl.

Journal of Clinical Microbiology, May 2003, p. 2261-2264, Vol. 41, No. 5
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.5.2261-2264.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hariprasad, S M, Mieler, W F, Lin, T K, Sponsel, W E, Graybill, J R (2008). Voriconazole in the treatment of fungal eye infections: a review of current literature. Br J Ophthalmol 92: 871-878 [Abstract] [Full Text]  
  • Troke, P., Aguirrebengoa, K., Arteaga, C., Ellis, D., Heath, C. H., Lutsar, I., Rovira, M., Nguyen, Q., Slavin, M., Chen, S. C. A., on behalf of the Global Scedosporium Study Group, (2008). Treatment of Scedosporiosis with Voriconazole: Clinical Experience with 107 Patients. Antimicrob. Agents Chemother. 52: 1743-1750 [Abstract] [Full Text]  
  • Espinel-Ingroff, A., Johnson, E., Hockey, H., Troke, P. (2008). Activities of voriconazole, itraconazole and amphotericin B in vitro against 590 moulds from 323 patients in the voriconazole Phase III clinical studies. J Antimicrob Chemother 61: 616-620 [Abstract] [Full Text]  
  • Cortez, K. J., Roilides, E., Quiroz-Telles, F., Meletiadis, J., Antachopoulos, C., Knudsen, T., Buchanan, W., Milanovich, J., Sutton, D. A., Fothergill, A., Rinaldi, M. G., Shea, Y. R., Zaoutis, T., Kottilil, S., Walsh, T. J. (2008). Infections Caused by Scedosporium spp.. Clin. Microbiol. Rev. 21: 157-197 [Abstract] [Full Text]  
  • Lalitha, P., Shapiro, B. L., Srinivasan, M., Prajna, N. V., Acharya, N. R., Fothergill, A. W., Ruiz, J., Chidambaram, J. D., Maxey, K. J., Hong, K. C., McLeod, S. D., Lietman, T. M. (2007). Antimicrobial Susceptibility of Fusarium, Aspergillus, and Other Filamentous Fungi Isolated From Keratitis. Arch Ophthalmol 125: 789-793 [Abstract] [Full Text]  
  • Thiel, M. A., Zinkernagel, A. S., Burhenne, J., Kaufmann, C., Haefeli, W. E. (2007). Voriconazole Concentration in Human Aqueous Humor and Plasma during Topical or Combined Topical and Systemic Administration for Fungal Keratitis. Antimicrob. Agents Chemother. 51: 239-244 [Abstract] [Full Text]  
  • Mancini, N., Ossi, C. M, Perotti, M., Carletti, S., Gianni, C., Paganoni, G., Matuska, S., Guglielminetti, M., Cavallero, A., Burioni, R., Rama, P., Clementi, M. (2005). Direct sequencing of Scedosporium apiospermum DNA in the diagnosis of a case of keratitis. J Med Microbiol 54: 897-900 [Abstract] [Full Text]  
  • Krishnan, S., Manavathu, E. K., Chandrasekar, P. H. (2005). A comparative study of fungicidal activities of voriconazole and amphotericin B against hyphae of Aspergillus fumigatus. J Antimicrob Chemother 55: 914-920 [Abstract] [Full Text]  
  • Schaenman, J. M., DiGiulio, D. B., Mirels, L. F., McClenny, N. M., Berry, G. J., Fothergill, A. W., Rinaldi, M. G., Montoya, J. G. (2005). Scedosporium apiospermum Soft Tissue Infection Successfully Treated with Voriconazole: Potential Pitfalls in the Transition from Intravenous to Oral Therapy. J. Clin. Microbiol. 43: 973-977 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»