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Journal of Clinical Microbiology, June 2003, p. 2659-2661, Vol. 41, No. 6
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.6.2659-2661.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular Epidemiology of Macrolide Resistance in Neonatal Bloodstream Isolates of Group B Streptococci

Daniel J. Diekema,1,2* Janet I. Andrews,3 Holly Huynh,2 Paul R. Rhomberg,4 Stella R. Doktor,5 Jill Beyer,5 Virginia D. Shortridge,5 Robert K. Flamm,5 Ronald N. Jones,4,6 and Michael A. Pfaller2,7

Department of Internal Medicine,1 Department of Pathology,2 Department of Epidemiology,7 Department of Obstetrics and Gynecology, University of Iowa Colleges of Medicine and Public Health, Iowa City,3 The Jones Group/Jones Microbiology Institute, North Liberty, Iowa,4 Infectious Diseases Microbiology, Abbott Laboratories, Abbott Park, Illinois,5 Department of Internal Medicine, Tufts University School of Medicine, Boston, Massachusetts6

Received 10 February 2003/ Returned for modification 16 March 2003/ Accepted 24 March 2003

Pulsed-field gel electrophoresis (PFGE) was performed on 122 neonatal bloodstream isolates of group B streptococci (GBS) to further examine the relationship between macrolide resistance and serotype V GBS (GBS-V). Over one-third (35%) of macrolide-resistant GBS belonged to a single PFGE subtype of GBS-V, which was also the most common GBS-V subtype noted in previous Centers for Disease Control and Prevention surveillance studies. Erm methylase (ermA and ermB) was the most common resistance mechanism detected, present in 12 of 20 macrolide-resistant GBS.

* Corresponding author. Mailing address: University of Iowa College of Medicine, C 606 GH, Iowa City, IA 52242. Phone: (319) 356-8615. Fax: (319) 356-4916. E-mail: daniel-diekema{at}uiowa.edu.

Journal of Clinical Microbiology, June 2003, p. 2659-2661, Vol. 41, No. 6
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.6.2659-2661.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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