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Journal of Clinical Microbiology, June 2003, p. 2763-2767, Vol. 41, No. 6
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.6.2763-2767.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Oncogenic Human Papillomavirus DNA Loads in Human Immunodeficiency Virus-Positive Women with High-Grade Cervical Lesions Are Strongly Elevated

S. J. Weissenborn,1* A. M. Funke,2 M. Hellmich,3 P. Mallmann,2 P. G. Fuchs,1,{dagger} H. J. Pfister,1 and U. Wieland1

Institute of Virology, University of Cologne, 50935 Cologne,1 Department of Obstetrics and Gynaecology,2 Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, 50931 Cologne, Germany3

Received 12 July 2002/ Returned for modification 29 November 2002/ Accepted 6 March 2003

Human papillomavirus (HPV) DNA loads of six oncogenic HPV types were measured by real-time PCR in cervical scrapes of human immunodeficiency virus (HIV)-infected and uninfected women. In both groups, HPV loads increased with the grade of cervical disease. HIV infection did not affect HPV loads in low-grade lesions but was associated with significantly higher HPV loads in severe dysplasia; highest loads were found in advanced HIV disease. Our data reflect the aggressive course of HPV infection in HIV-positive women.

* Corresponding author. Mailing address: Institute of Virology, University of Cologne, Fuerst-Pueckler Strasse 56, 50935 Cologne, Germany. Phone: 49 221 478-3912. Fax: 49 221 478-3904. E-mail: soenke.weissenborn{at}medizin.uni-koeln.de.

{dagger} Deceased 10 July 2002.

Journal of Clinical Microbiology, June 2003, p. 2763-2767, Vol. 41, No. 6
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.6.2763-2767.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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