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Journal of Clinical Microbiology, June 2003, p. 2763-2767, Vol. 41, No. 6
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.6.2763-2767.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Oncogenic Human Papillomavirus DNA Loads in Human Immunodeficiency Virus-Positive Women with High-Grade Cervical Lesions Are Strongly Elevated

S. J. Weissenborn,^1* A. M. Funke,² M. Hellmich,³ P. Mallmann,² P. G. Fuchs,^1, H. J. Pfister,¹ and U. Wieland¹

Institute of Virology, University of Cologne, 50935 Cologne,¹ Department of Obstetrics and Gynaecology,² Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, 50931 Cologne, Germany³

Received 12 July 2002/ Returned for modification 29 November 2002/ Accepted 6 March 2003

Human papillomavirus (HPV) DNA loads of six oncogenic HPV types were measured by real-time PCR in cervical scrapes of human immunodeficiency virus (HIV)-infected and uninfected women. In both groups, HPV loads increased with the grade of cervical disease. HIV infection did not affect HPV loads in low-grade lesions but was associated with significantly higher HPV loads in severe dysplasia; highest loads were found in advanced HIV disease. Our data reflect the aggressive course of HPV infection in HIV-positive women.

Deceased 10 July 2002.

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