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Journal of Clinical Microbiology, July 2003, p. 3158-3162, Vol. 41, No. 7
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.7.3158-3162.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Rotavirus Diarrhea Severity Is Related to the VP4 Type in Mexican Children

Felipe Mota-Hernández,1* Juan José Calva,2 Claudia Gutiérrez-Camacho,1 Sofía Villa-Contreras,3 Carlos F. Arias,4 Luis Padilla-Noriega,4,5 Héctor Guiscafré-Gallardo,3 María de Lourdes Guerrero,2 Susana López,4 Onofre Muñoz,3 Juan F. Contreras,6 Roberto Cedillo,3 Ismael Herrera,7 and Fernando I. Puerto8

Departamento de Medicina Comunitaria e Hidratación Oral, Hospital Infantil de México Federico Gómez, Mexico City,1 Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City,2 Instituto Mexicano del Seguro Social, Mexico City,3 Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos,4 Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City,5 Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León,6 Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, San Luis Potosí,7 Centro de Investigaciones Regionales "Hideyo Noguchi," Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico8

Received 16 April 2002/ Returned for modification 18 August 2002/ Accepted 8 February 2003

This report is of a community-based case control study to assess whether the severity of acute diarrhea by rotavirus (RV) in young children is associated with a particular VP7 (G) or VP4 (P) RV serotype. Five hundred twenty children younger than 2 years of age with diarrhea lasting less than 3 days were age and gender matched with 520 children with no diarrhea. The G and P serotypes were determined with specific monoclonal antibodies, and the VP4 serotype specificity in a subgroup was confirmed by genotyping. Infection with a G3 serotype led to a higher risk of diarrhea than infection with a G1 serotype. Infection with a G3-nontypeable-P serotype was associated with more severe gastroenteritis than infection with a G3 (or G1) P1A[8] serotype. A child with diarrhea-associated dehydration was almost five times more likely to be infected with a G3-nontypeable-P serotype than a child without dehydration (P < 0.001). Moreover, the two predominant monotypes within serotype P1A[8] had significantly different clinical manifestations. In this study, the severity of RV-associated diarrhea was related to different P serotypes rather than to G serotypes. The relationship between serotype and clinical outcomes seems to be complex and to vary among different geographic areas.

* Corresponding author. Mailing address: Departamento de Investigación en Medicina Comunitaria e Hidratación Oral, Hospital Infantil de México Federico Gómez, Calle Dr. Márquez 162, Mexico City 06720, Mexico. E-mail: fmota{at}mail.ssa.gob.mx.

Journal of Clinical Microbiology, July 2003, p. 3158-3162, Vol. 41, No. 7
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.7.3158-3162.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mendez-Toss, M., Griffin, D. D., Calva, J., Contreras, J. F., Puerto, F. I., Mota, F., Guiscafre, H., Cedillo, R., Munoz, O., Herrera, I., Lopez, S., Arias, C. F. (2004). Prevalence and Genetic Diversity of Human Astroviruses in Mexican Children with Symptomatic and Asymptomatic Infections. J. Clin. Microbiol. 42: 151-157 [Abstract] [Full Text]  


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