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Journal of Clinical Microbiology, July 2003, p. 3376-3378, Vol. 41, No. 7
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.7.3376-3378.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Differences in the Frequency of Resistance to Antiretroviral Drug Classes among Human Immunodeficiency Virus Type 1 Clinical Isolates

Rafael E. Campo,1* Paola N. Lichtenberger,1 Isabella Rosa,2 German Suarez,2 Fernando A. Rivera,2 Allan E. Rodriguez,1 Dushyantha T. Jayaweera,1 Natalie A. Wahlay,3 and Michael A. Kolber1

Division of Infectious Diseases,1 Department of Medicine,2 Department of Epidemiology and Public Health, University of Miami School of Medicine, Miami, Florida3

Received 24 October 2002/ Returned for modification 26 February 2003/ Accepted 7 April 2003

Genotypic resistance to all antiretroviral classes was widespread among human immunodeficiency virus type 1 isolates failing therapy. Resistance to nonnucleoside reverse transcriptase inhibitors was found most frequently and resistance to protease inhibitors was found least frequently, most likely due to differences in the number of enzymatic amino acid substitutions leading to resistance to each particular drug class.

* Corresponding author. Mailing address: Division of Infectious Diseases, 1500 NW 12th Ave., 8th Floor W., Miami, FL 33136. Phone: (305) 243-5621. Fax: (305) 243-3005. E-mail: rcampo{at}med.miami.edu.

Journal of Clinical Microbiology, July 2003, p. 3376-3378, Vol. 41, No. 7
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.7.3376-3378.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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