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Journal of Clinical Microbiology, July 2003, p. 3403-3406, Vol. 41, No. 7
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.7.3403-3406.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Outbreak of Carbapenem-Resistant Acinetobacter baumannii Producing the OXA-23 Enzyme in Curitiba, Brazil

Libera M. Dalla-Costa,1 Juliana M. Coelho,2* Helena A. P. H. M. Souza,1 Maria E. S. Castro,1 Christiane J. N. Stier,1 Karin L. Bragagnolo,1 Alvaro Rea-Neto,1 Sergio R. Penteado-Filho,3 David M. Livermore,2 and Neil Woodford2

Hospital de Clínicas da Universidade Federal do Paraná (HC),1 Hospital Universitário Evangélico de Curitiba (HUEC), Curitiba, Brazil,3 Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency, Colindale, London NW9 5HT, United Kingdom2

Received 29 January 2003/ Returned for modification 26 March 2003/ Accepted 3 April 2003

Carbapenem-resistant Acinetobacter baumannii isolates were obtained from eight patients in two hospitals in Curitiba, Brazil. The isolates were multiresistant, belonged to a single strain, and produced the OXA-23 carbapenemase. Treatment options were limited, although the isolates were susceptible to polymyxin B in vitro. The strain contributed to the deaths of five patients.

* Corresponding author. Mailing address: ARMRL, CPHL, Health Protection Agency, 61 Colindale Ave., London NW9 5HT, United Kingdom. Phone: 44-20-8200-4400. Fax: 44-20-8358-3292. E-mail: juliana.coelho{at}hpa.org.uk.

Journal of Clinical Microbiology, July 2003, p. 3403-3406, Vol. 41, No. 7
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.7.3403-3406.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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