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Journal of Clinical Microbiology, August 2003, p. 3542-3547, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3542-3547.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Outbreak of Extended-Spectrum ß-Lactamase VEB-1-Producing Isolates of Acinetobacter baumannii in a French Hospital

Laurent Poirel,1 Olivier Menuteau,1 Nathalie Agoli,2 Christian Cattoen,2 and Patrice Nordmann1*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre,1 Service de Biologie Clinique, CHG Valenciennes, France2

Received 30 January 2003/ Returned for modification 1 May 2003/ Accepted 3 May 2003

Twelve clonally related and multidrug-resistant Acinetobacter baumannii isolates were recovered during a 4-month period from 12 patients hospitalized at the Valenciennes Hospital in France. Antibiograms determined by the double-disk diffusion technique on cloxacillin-containing plates detected a clavulanic acid-inhibited extended-spectrum ß-lactamase (ESBL). PCR and sequencing identified the gene encoding the Ambler class A ESBL VEB-1. This gene was located on the chromosome and was part of a class 1 integron identical to that previously identified in Pseudomonas aeruginosa isolates from Thailand. Additionally, seven clonally related blaVEB-1-positive A. baumannii strains were identified in the immediate environment of the hospitalized patients. This is the first report of the ESBL VEB-1 in Acinetobacter spp. and the first description of VEB-1-producing strains as a source of an outbreak occurring outside Southeast Asia. This report underlines the difficulty of the identification of ESBLs in A. baumannii.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Journal of Clinical Microbiology, August 2003, p. 3542-3547, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3542-3547.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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