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Journal of Clinical Microbiology, August 2003, p. 3851-3853, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3851-3853.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Evaluation of a Rapid PCR Assay for Diagnosis of Meningococcal Meningitis

David C. Richardson, Lisa Louie, Marie Louie, and Andrew E. Simor*

Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

Received 6 February 2003/ Returned for modification 16 March 2003/ Accepted 12 May 2003

We compared the results of Gram staining and culture of cerebrospinal fluid to results obtained with a rapid PCR assay for the diagnosis of meningococcal meningitis in 281 cases of suspected bacterial meningitis. PCR had a sensitivity of 97% compared to a sensitivity of 55% for culture, and the PCR specificity was 99.6%. PCR results were available within 2 h of the start of the assay.

* Corresponding author. Mailing address: Dept. of Microbiology, Sunnybrook and Women's College Health Sciences Centre, B121-2075 Bayview Ave., Toronto, Ontario, Canada M4N 3M5. Phone: (416) 480-4549. Fax: (416) 480-6845. E-mail: andrew.simor{at}sw.ca.

Journal of Clinical Microbiology, August 2003, p. 3851-3853, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3851-3853.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Poppert, S., Essig, A., Stoehr, B., Steingruber, A., Wirths, B., Juretschko, S., Reischl, U., Wellinghausen, N. (2005). Rapid Diagnosis of Bacterial Meningitis by Real-Time PCR and Fluorescence In Situ Hybridization. J. Clin. Microbiol. 43: 3390-3397 [Abstract] [Full Text]  


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