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Journal of Clinical Microbiology, August 2003, p. 3864-3867, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3864-3867.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Improved Molecular Detection of Dengue Virus Serotype 1 Variants

Institut Pasteur du Cambodge,¹ National Dengue Control Programme, Ministry of Health,² World Health Organization, Phnom Penh, Cambodia³

Received 10 September 2002/ Returned for modification 26 February 2003/ Accepted 23 May 2003

The dengue virus molecular typing method described by Lanciotti and coworkers (R. S. Lanciotti, C. H. Calisher, D. J. Gubler, G. J. Chang, and A. Vance-Vorndam, J. Clin. Microbiol. 30:545-551, 1992) is used worldwide for diagnosis and surveillance. However, it failed to detect DENV-1 variants in Cambodia due to a point mutation. We describe an improvement of the method that allows the detection of additional DENV-1 strains, including potential variants.

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