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Journal of Clinical Microbiology, August 2003, p. 3897-3900, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3897-3900.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Evaluation of Susceptibility of Human Herpesvirus 8 to Antiviral Drugs by Quantitative Real-Time PCR

Yan Sergerie and Guy Boivin*

Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Québec (Pavillon CHUL), and Université Laval, Québec, Canada

Received 14 February 2003/ Returned for modification 24 April 2003/ Accepted 4 May 2003

A new in vitro system based on real-time PCR was developed for evaluation of human herpesvirus 8 susceptibility to antiviral agents. Cidofovir had the greatest inhibitory activity against HHV-8 (50% inhibitory concentration [IC50], 0.43 µM) followed by ganciclovir (2.61 µM), adefovir (18.00 µM), acyclovir (31.00 µM), and foscarnet (34.15 µM). The potential therapeutic efficacy for HHV-8 (i.e., peak serum drug level/IC50) is highest for cidofovir (167) and foscarnet (22).

* Corresponding author. Mailing address: Centre de Recherche en Infectiologie, Centre Hospitalier Universitaire de Québec, Pavillon CHUL, 2705 Blvd Laurier, Ste-Foy, QC, G1V 4G2 Canada. Phone: (418) 654-2705. Fax: (418) 654-2715. E-mail: Guy.Boivin{at}crchul.ulaval.ca.

Journal of Clinical Microbiology, August 2003, p. 3897-3900, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3897-3900.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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