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Analysis of the Ability of Spirochete Species Associated with Relapsing Fever, Avian Borreliosis, and Epizootic Bovine Abortion To Bind Factor H and Cleave C3b

Department of Microbiology and Immunology, Center for the Study of Biological Complexity,¹ Division of Infectious Diseases, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298²

Received 6 March 2003/ Returned for modification 14 April 2003/ Accepted 11 May 2003

Some Borrelia species associated with Lyme disease bind the complement-regulatory protein factor H (fH), a process that may aid in immune evasion. In this report we demonstrate that some Borrelia species associated with relapsing fever bind fH, but not those associated with avian borreliosis and epizootic bovine abortion. Cell-bound fH was also found to mediate cleavage of exogenously supplied human C3b, demonstrating the biological relevance of fH binding and its possible importance in the pathogenesis of the relapsing-fever spirochetes.

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