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Journal of Clinical Microbiology, August 2003, p. 3915-3918, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3915-3918.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Molecular Epidemiology of Haemophilus influenzae Type b Isolated from Children with Clinical Cases of Conjugate Vaccine Failures

José Campos,* Belén Aracil, Federico Román, María Pérez-Vázquez, and the Collaborative Group for Hib Vaccine Failures{dagger},

Centro Nacional de Microbiología, Instituto de Salud Carlos III, Ministry of Health, Madrid, Spain

Received 31 March 2003/ Returned for modification 7 May 2003/ Accepted 23 May 2003

We analyzed eight invasive Haemophilus influenzae strains isolated from individual children vaccinated appropriately for their ages. Five of the strains were type b and three were nontypeable strains. Children infected with nontypeable strains had a protective level of anti-H. influenzae type b antibodies, while only one of the children whose cases represented true vaccine failure did.

* Corresponding author. Mailing address: Centro Nacional de Microbiología, Instituto de Salud Carlos III, Carretera de Pozuelo s/n, 28220 Majadahonda, Madrid, Spain. Phone: 34 91 509 7901. Fax: 34 91 509 7966. E-mail: jcampos{at}isciii.es.

{dagger} Members of the Collaborative Group for Hib Vaccine Failures are acknowledged at the end of the article.

Journal of Clinical Microbiology, August 2003, p. 3915-3918, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3915-3918.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Aracil, B., Slack, M., Perez-Vazquez, M., Roman, F., Ramsay, M., Campos, J. (2006). Molecular Epidemiology of Haemophilus influenzae Type b Causing Vaccine Failures in the United Kingdom.. J. Clin. Microbiol. 44: 1645-1649 [Abstract] [Full Text]  


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