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Journal of Clinical Microbiology, August 2003, p. 3929-3932, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3929-3932.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Genomic Analysis of Mycobacterium tuberculosis Complex Strains Used for Production of Purified Protein Derivative

Jacqueline Inwald,1 Jason Hinds,2 Si Palmer,1 James Dale,1 Philip D. Butcher,2 R. Glyn Hewinson,1 and Stephen V. Gordon1*

TB Research Group, Veterinary Laboratories Agency (Weybridge), New Haw, Addlestone, Surrey KT15 3NB,1 Bacterial Microarray Group, Department of Cellular and Molecular Medicine, St. George's Hospital Medical School, London SW17 0RE, United Kingdom2

Received 14 February 2003/ Returned for modification 12 May 2003/ Accepted 16 May 2003

The genomes of the tuberculin production strains Mycobacterium bovis AN5 and Mycobacterium tuberculosis DT were compared to genome-sequenced tubercle bacilli by using DNA microarrays. Neither the AN5 nor DT strain suffered extensive gene deletions during in vitro passage. This suggests that bovine tuberculin made from M. bovis AN5 is suitable to detect infection with presently prevalent M. bovis strains.

* Corresponding author. Mailing address: TB Research Group, Veterinary Laboratories Agency Weybridge, Woodham Ln., New Haw, Addlestone, Surrey KT15 3NB, United Kingdom. Phone: (44) 01932 357860. Fax: (44) 01932 357684. E-mail: s.v.gordon{at}vla.defra.gsi.gov.uk.

Journal of Clinical Microbiology, August 2003, p. 3929-3932, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3929-3932.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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