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Journal of Clinical Microbiology, August 2003, p. 3955-3959, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3955-3959.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Vertical Transmission of the Hepatitis C Virus to Infants of Anti-Human Immunodeficiency Virus-Negative Mothers: Molecular Evolution of Hypervariable Region 1 in Prenatal and Perinatal or Postnatal Infections

C. Caudai,1* M. Battiata,1 M. P. Riccardi,2 M. Toti,2 P. Bonazza,3 M. G. Padula,1 M. Pianese,1 and P. E. Valensin1

Department of Molecular Biology, Microbiology Section, University of Siena, Siena,1 Division of Infectious Disease,2 Division of Pediatrics, Misericordia Hospital, Grosseto, Italy3

Received 3 March 2003/ Returned for modification 20 April 2003/ Accepted 23 May 2003

In a prospective study of 33 infants born to hepatitis C virus (HCV)-positive human immunodeficiency virus-negative mothers the vertical transmission of HCV occurred in 6.8%. The evolution of HCV infection in two babies was studied from birth up to 5 or 6 years of age, and the sequencing of the hypervariable region (HVR) of the putative envelope-encoding E2 region of the HCV genome was performed. The HVR1 sequence variability and the different serological profiles during follow-up could reflect the differences in HCV transmission routes, HCV genotypes, and clinical evolution of infection.

* Corresponding author. Mailing address: Department of Molecular Biology, Microbiology Section, University of Siena, via Laterina 8, 53100 Siena, Italy. Phone: 39-577-233850. Fax: 39-577-233870. E-mail: caudai{at}unisi.it.

Journal of Clinical Microbiology, August 2003, p. 3955-3959, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3955-3959.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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