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Journal of Clinical Microbiology, August 2003, p. 3964-3966, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3964-3966.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

babA2- and cagA-Positive Helicobacter pylori Strains Are Associated with Duodenal Ulcer and Gastric Carcinoma in Brazil

Adriana Gonçalves Oliveira,1 Adriana Santos,1 Juliana Becattini Guerra,1 Gifone Aguiar Rocha,1 Andreia Maria Camargos Rocha,1 Celso Affonso Oliveira,1 Mônica Maria Demas Álvares Cabral,2 Ana Margarida Miguel Ferreira Nogueira,2 and Dulciene Maria Magalhães Queiroz1*

Laboratory of Research in Bacteriology,1 Department of Pathology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil2

Received 16 April 2003/ Returned for modification 28 May 2003/ Accepted 1 June 2003

The babA2 and cagA genes were investigated in 208 Brazilian Helicobacter pylori strains. A strong association between babA2 and duodenal ulcer or gastric carcinoma was observed, even after adjusting for confounding factors, such as age, gender, and cagA status. cagA-positive strains were also independently associated with H. pylori-related diseases.

* Corresponding author. Mailing address: Laboratory of Research in Bacteriology, Faculdade de Medicina, Av. Alfredo Balena, 190/4026, 30130-100 Belo Horizonte, Minas Gerais, Brazil. Phone and fax: 55 31 3274 2767. E-mail: dqueiroz{at}medicina.ufmg.br.

Journal of Clinical Microbiology, August 2003, p. 3964-3966, Vol. 41, No. 8
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.8.3964-3966.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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