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Journal of Clinical Microbiology, September 2003, p. 4462-4464, Vol. 41, No. 9
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.9.4462-4464.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

In Vivo Development of Quinolone Resistance in Salmonella enterica Serotype Typhimurium DT104

Malthe A. Melau Kristiansen,1* Dorthe Sandvang,2 and Thorkild Bremholm Rasmussen3

Department of Clinical Microbiology, Research Unit for Clinical Microbiology, University of Southern Denmark, 6400 Sønderborg,1 Statens Serum Institut, 2300 Copenhagen,2 Department of Surgery A, Odense University Hospital, 5000 Odense, Denmark3

Received 24 March 2003/ Returned for modification 1 May 2003/ Accepted 2 June 2003

Salmonella enterica serotype Typhimurium definitive phage type 104 was isolated several times from the same patient over a period of 2 years. The strain developed reduced sensitivity to fluoroquinolones, and a mutation in the gyrA gene that is associated with reduced sensitivity to quinolones was identified.

* Corresponding author. Mailing address: Department of Clinical Microbiology, Research Unit for Clinical Microbiology, University of Southern Denmark, Sønderborg Sygehus, Sydvang 1, 6400 Sønderborg, Denmark. Phone: 45 22 17 60 86. Fax: 45 74 18 27 43. E-mail: makblast{at}hotmail.com.

Journal of Clinical Microbiology, September 2003, p. 4462-4464, Vol. 41, No. 9
0095-1137/03/$08.00+0     DOI: 10.1128/JCM.41.9.4462-4464.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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