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Journal of Clinical Microbiology, January 2004, p. 362-365, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.362-365.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Possible High Rate of Transmission of Nontypeable Haemophilus influenzae, Including ß-Lactamase-Negative Ampicillin-Resistant Strains, between Children and Their Parents

Hiroshi Watanabe,1* Kazuhiko Hoshino,1 Rinya Sugita,2 Norichika Asoh,1 Kiwao Watanabe,1 Kazunori Oishi,1 and Tsuyoshi Nagatake1

Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki,1 Sugita Otorhinolaryngologic Clinic, Chiba, Japan2

Received 14 July 2003/ Returned for modification 26 August 2003/ Accepted 30 September 2003

The possible transmission of nontypeable Haemophilus influenzae between children and their parents was evaluated in 18 pairs of subjects from 15 families. Of the 33 isolates, 31 were found to be ß-lactamase negative, including 10 ß-lactamase-negative, ampicillin (AMP)-resistant (BLNAR) strains (AMP MIC, >=1.0 µg/ml) and 2 were ß-lactamase producing. Molecular typing by pulsed-field gel electrophoresis (PFGE) showed that 10 BLNAR isolates had 6 patterns, 23 non-BLNAR isolates had 13 patterns, and these patterns were different from each other, except for 1 pattern. As a result, the PFGE patterns in 14 of 18 pairs were indistinguishable and those in 4 pairs were different. These data indicate a possible high rate of intrafamilial transmission of nontypeable H. influenzae, including BLNAR strains, between children and their parents.

* Corresponding author. Mailing address: Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. Phone: 81 (95) 849-7842. Fax: 81 (95) 849-7843. E-mail: h-wata{at}net.nagasaki-u.ac.jp.

Journal of Clinical Microbiology, January 2004, p. 362-365, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.362-365.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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