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Journal of Clinical Microbiology, January 2004, p. 378-379, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.378-379.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Improving the Bacteriological Diagnosis of Tuberculous Meningitis

Guy E. Thwaites,1,2* Tran Thi Hong Chau,3 and Jeremy J. Farrar1,2

Oxford University Clinical Research Unit,1 Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam,3 Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom2

Received 17 June 2003/ Returned for modification 14 August 2003/ Accepted 20 September 2003

We made a bacteriological diagnosis of tuberculous meningitis in 107 of 132 (81%) adults with clinical tuberculous meningitis: acid-fast bacilli were seen in 77 of 132 (58%) and cultured from 94 of 132 (71%). Volume of cerebrospinal fluid, duration of symptoms, cerebrospinal fluid neutrophils, lactate, and glucose were all independently associated with bacteriological confirmation.

* Corresponding author. Mailing address: The University of Oxford Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam. Phone: 84 88 923 7954. Fax: 84 88 923 8904. E-mail: gthwaites{at}hcm.vnn.vn.

Journal of Clinical Microbiology, January 2004, p. 378-379, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.378-379.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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