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Journal of Clinical Microbiology, January 2004, p. 393-397, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.393-397.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Eight-Year Survey of Human Rotavirus Strains Demonstrates Circulation of Unusual G and P Types in Hungary

Krisztián Bányai,1,2 Jon R. Gentsch,2 Roger I. Glass,2 Mária Új,1 Ilona Mihály,3 and György Szücs1*

Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pécs,1 Laboratory for Diagnostic Virology, "St. Laszlo" Central Hospital for Infectious Diseases, Budapest, Hungary,3 Viral Gastroenteritis Section, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia2

Received 14 May 2003/ Returned for modification 14 July 2003/ Accepted 4 October 2003

Between 1992 and 2000, a total of 4,173 rotavirus-positive samples were collected from two areas of Hungary. Of these, 2,020 specimens (48.4%) were analyzed for G serotype, using monoclonal antibody-based immunoassay and reverse transcription-PCR. By the two methods, 1,789 samples were specified as G1 (62%), G2 (12.2%), G3 (1.4%), G4 (6.4%), G6 (1.0%), G9 (2.9%), or mixed infection (2.6%), and the remaining 231 (11.4%) could not be G typed. The linkage between G and P type, subgroup specificity, and RNA profile was investigated with a sample subset. Among these specimens, we identified both the four globally common strains (P[8],G1 subgroup II (sgII); P[4],G2 sgI; P[8],G3 sgII; and P[8],G4 sgII) and six uncommon strains (P[6],G4 sgII; P[9],G3 sgI; P[9],G6 sgI; P[14],G6 sgI; P[8],G9 sgII; and P[8],G9 sgI). All strains with P[8], P[6], P[9], and P[14] specificities had a long electropherotype, whereas most of those carrying a P[4] specificity were associated with a short electropherotype. Although once considered to be rare, P[9],G6 and P[8],G9 rotavirus strains represent potentially important new serotypes in Hungary.

* Corresponding author. Mailing address: Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Szabadság út 7, Pécs, H-7623, Hungary. Phone: 36 72 514 970. Fax: 36 72 514 949. E-mail: gszucs{at}main.antszbar.hu.

Journal of Clinical Microbiology, January 2004, p. 393-397, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.393-397.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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