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Journal of Clinical Microbiology, January 2004, p. 461-466, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.461-466.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Genetic Diversity and Population Structure of Mycobacterium tuberculosis in Casablanca, a Moroccan City with High Incidence of Tuberculosis

Loubna Tazi,1* Jamila El Baghdadi,2 Sarah Lesjean,3 Camille Locht,3 Philip Supply,3 Michel Tibayrenc,1 and Anne-Laure Bañuls1

Génétique des Maladies Infectieuses, UMR CNRS-IRD 9926, IRD, 34394 Montpellier Cedex 5,1 Laboratoire des Mécanismes Moléculaires de la Pathogenèse Bactérienne, INSERM U447, Institut Pasteur de Lille, F-59019 Lille Cedex, France,3 Service des Mycobactéries, Institut Pasteur du Maroc, Casablanca, Morocco2

Received 31 March 2003/ Returned for modification 11 June 2003/ Accepted 11 August 2003

Although lower-resource countries have by far the highest burden of tuberculosis, knowledge of Mycobacterium tuberculosis population structure and genetic diversity in these regions remains almost nonexistent. In this paper, 150 Moroccan M. tuberculosis isolates circulating in Casablanca were genotyped by random amplified polymorphic DNA analysis using 10 different primers and by mycobacterial interspersed repetitive units-variable number of tandem repeats typing at 12 loci. The population genetic tests revealed a basically clonal structure for this population, without excluding rare genetic exchanges. Genetic analysis also showed a notable genetic polymorphism for the species M. tuberculosis, a weak cluster individualization, and an unexpected genetic diversity for a population in such a high-incidence community. Phylogenetic analyses of this Moroccan sample also supported that these isolates are genetically heterogeneous.

* Corresponding author. Present address: Department of Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine CA 92697-2525. Phone: (949) 824-8295. Fax: (949) 824-2474. E-mail: ltazi{at}uci.edu.

Journal of Clinical Microbiology, January 2004, p. 461-466, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.461-466.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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