This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hansen, S. M.
Right arrow Articles by Sørensen, U. B. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hansen, S. M.
Right arrow Articles by Sørensen, U. B. S.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, January 2004, p. 83-89, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.83-89.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Dynamics of Streptococcus agalactiae Colonization in Women during and after Pregnancy and in Their Infants

Søren Mose Hansen,1 Niels Uldbjerg,2 Mogens Kilian,1 and Uffe B. Skov Sørensen1*

Department of Medical Microbiology and Immunology, The University of Aarhus, DK-8000 Aarhus C,1 Department of Obstetrics, Aarhus University Hospital, Skejby, DK-8200 Aarhus N, Denmark2

Received 22 July 2003/ Returned for modification 12 September 2003/ Accepted 24 September 2003

The population dynamics of Streptococcus agalactiae (group B streptococci [GBS]) colonization of the vagina and anorectal area was investigated in a cohort of 77 Danish women during and after their pregnancy by a new sensitive method. The mean carriage rate among individual observations was 36%, and the cumulative carriage rate over the entire observation period was 54%. Examination of more than 1,500 GBS isolates by pulsed-field gel electrophoresis demonstrated that the GBS population was remarkably homogeneous and stable in each carrier. Virtually all carriers were colonized by a single GBS clone on all occasions spanning up to 2 years. Repeated detection of the same clone even in women who were recorded as intermittent carriers suggests that the actual carrier rate exceeds 50% but that fluctuations in the GBS proportions of the flora occasionally preclude their detection. Newborns and young infants usually carried the same GBS clone as their mothers. However, only twice were identical clones of GBS detected in different women in contrast to the observed clonal relationships of clinical isolates. These observations strongly suggest differences in the properties and epidemiology of virulent GBS clones compared to clones commonly carried by healthy individuals.

* Corresponding author. Mailing address: Department of Medical Microbiology and Immunology, The Bartholin Building, The University of Aarhus, DK8000 Aarhus C, Denmark. Phone: (45) 89421740. Fax: (45) 86196128. E-mail: uss{at}microbiology.au.dk.

Journal of Clinical Microbiology, January 2004, p. 83-89, Vol. 42, No. 1
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.1.83-89.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Doro, F., Liberatori, S., Rodriguez-Ortega, M. J., Rinaudo, C. D., Rosini, R., Mora, M., Scarselli, M., Altindis, E., D'Aurizio, R., Stella, M., Margarit, I., Maione, D., Telford, J. L., Norais, N., Grandi, G. (2009). Surfome Analysis as a Fast Track to Vaccine Discovery: IDENTIFICATION OF A NOVEL PROTECTIVE ANTIGEN FOR GROUP B STREPTOCOCCUS HYPERVIRULENT STRAIN COH1. Mol. Cell. Proteomics 8: 1728-1737 [Abstract] [Full Text]  
  • Manning, S. D., Springman, A. C., Lehotzky, E., Lewis, M. A., Whittam, T. S., Davies, H. D. (2009). Multilocus Sequence Types Associated with Neonatal Group B Streptococcal Sepsis and Meningitis in Canada. J. Clin. Microbiol. 47: 1143-1148 [Abstract] [Full Text]  
  • Cutler, R. R., Odent, M., Hajj-Ahmad, H., Maharjan, S., Bennett, N. J., Josling, P. D., Ball, V., Hatton, P., Dall'Antonia, M. (2009). In vitro activity of an aqueous allicin extract and a novel allicin topical gel formulation against Lancefield group B streptococci. J Antimicrob Chemother 63: 151-154 [Abstract] [Full Text]  
  • Kimura, K., Suzuki, S., Wachino, J.-i., Kurokawa, H., Yamane, K., Shibata, N., Nagano, N., Kato, H., Shibayama, K., Arakawa, Y. (2008). First Molecular Characterization of Group B Streptococci with Reduced Penicillin Susceptibility. Antimicrob. Agents Chemother. 52: 2890-2897 [Abstract] [Full Text]  
  • Nobbs, A. H., Rosini, R., Rinaudo, C. D., Maione, D., Grandi, G., Telford, J. L. (2008). Sortase A Utilizes an Ancillary Protein Anchor for Efficient Cell Wall Anchoring of Pili in Streptococcus agalactiae. Infect. Immun. 76: 3550-3560 [Abstract] [Full Text]  
  • Martins, E. R., Pessanha, M. A., Ramirez, M., Melo-Cristino, J., and the Portuguese Group for the Study of Streptoc, (2007). Analysis of Group B Streptococcal Isolates from Infants and Pregnant Women in Portugal Revealing Two Lineages with Enhanced Invasiveness. J. Clin. Microbiol. 45: 3224-3229 [Abstract] [Full Text]  
  • Busetti, M., D'Agaro, P., Campello, C. (2007). Group B streptococcus prevalence in pregnant women from North-Eastern Italy: advantages of a screening strategy based on direct plating plus broth enrichment. J. Clin. Pathol. 60: 1140-1143 [Abstract] [Full Text]  
  • Berardi, A., Lugli, L., Baronciani, D., Creti, R., Rossi, K., Ciccia, M., Gambini, L., Mariani, S., Papa, I., Serra, L., Tridapalli, E., Ferrari, F., for the GBS Prevention Working Group of Emilia-Rom, (2007). Group B Streptococcal Infections in a Northern Region of Italy. Pediatrics 120: e487-e493 [Abstract] [Full Text]  
  • Bergseng, H., Bevanger, L., Rygg, M., Bergh, K. (2007). Real-time PCR targeting the sip gene for detection of group B streptococcus colonization in pregnant women at delivery. J Med Microbiol 56: 223-228 [Abstract] [Full Text]  
  • Eriksen, K. T., Haubek, D., Poulsen, K. (2005). Intragenomic recombination in the highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans. Microbiology 151: 3371-3379 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»