This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Trilles, L. Articles by Guarro, J. Search for Related Content PubMed PubMed Citation Articles by Trilles, L. Articles by Guarro, J.

In Vitro Antifungal Susceptibility of Cryptococcus gattii

Serviçio de Micología Médica, Instituto de Pesquisa Clínica Evandro Chagas, FIOCRUZ, Rio de Janeiro, Brazil,¹ Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain²

Received 3 March 2004/ Returned for modification 3 May 2004/ Accepted 12 June 2004

We have determined the in vitro susceptibilities of 57 strains of Cryptococcus gattii to nine antifungal agents and have compared the MICs for these strains with those for C. neoformans. MICs were determined by a microdilution reference method. Albaconazole and ravuconazole (MICs of 0.04 and 0.05 µg/ml, respectively) showed the best activities. Micafungin showed no activity (MIC of >128 µg/ml). In general, C. gattii was less susceptible than C. neoformans to all drugs tested, with the exception of amphotericin B and flucytosine.

This article has been cited by other articles:

• Pasqualotto, A. C., Denning, D. W. (2008). New and emerging treatments for fungal infections. J Antimicrob Chemother 61: i19-i30 [Abstract] [Full Text]  
• Khan, Z. U., Randhawa, H. S., Kowshik, T., Chowdhary, A., Chandy, R. (2007). Antifungal susceptibility of Cryptococcus neoformans and Cryptococcus gattii isolates from decayed wood of trunk hollows of Ficus religiosa and Syzygium cumini trees in north-western India. J Antimicrob Chemother 60: 312-316 [Abstract] [Full Text]  
• Pfaller, M. A., Diekema, D. J., Gibbs, D. L., Newell, V. A., Meis, J. F., Gould, I. M., Fu, W., Colombo, A. L., Rodriguez-Noriega, E., and the Global Antifungal Surveillance Group, (2007). Results from the ARTEMIS DISK Global Antifungal Surveillance Study, 1997 to 2005: an 8.5-Year Analysis of Susceptibilities of Candida Species and Other Yeast Species to Fluconazole and Voriconazole Determined by CLSI Standardized Disk Diffusion Testing. J. Clin. Microbiol. 45: 1735-1745 [Abstract] [Full Text]  
• Jain, N., Li, L., McFadden, D. C., Banarjee, U., Wang, X., Cook, E., Fries, B. C. (2006). Phenotypic Switching in a Cryptococcus neoformans Variety gattii Strain Is Associated with Changes in Virulence and Promotes Dissemination to the Central Nervous System. Infect. Immun. 74: 896-903 [Abstract] [Full Text]  
• Trilles, L., Fernandez-Torres, B., dos Santos Lazera, M., Wanke, B., de Oliveira Schubach, A., de Almeida Paes, R., Inza, I., Guarro, J. (2005). In Vitro Antifungal Susceptibilities of Sporothrix schenckii in Two Growth Phases. Antimicrob. Agents Chemother. 49: 3952-3954 [Abstract] [Full Text]  
• Serena, C., Fernandez-Torres, B., Pastor, F. J., Trilles, L., Lazera, M. d. S., Nolard, N., Guarro, J. (2005). In Vitro Interactions of Micafungin with Other Antifungal Drugs against Clinical Isolates of Four Species of Cryptococcus. Antimicrob. Agents Chemother. 49: 2994-2996 [Abstract] [Full Text]