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Journal of Clinical Microbiology, October 2004, p. 4832-4834, Vol. 42, No. 10
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.10.4832-4834.2004

Universal High-Level Primary Metronidazole Resistance in Helicobacter pylori Isolated from Children in Egypt

May Sherif,1 Zaynab Mohran,1 Hanan Fathy,2 David M. Rockabrand,1 Patrick J. Rozmajzl,1 and Robert W. Frenck1*

Naval Medical Research Unit No. 3,1 Abu El-Reesh Children's Hospital, Cairo, Egypt2

Received 26 February 2004/ Returned for modification 29 March 2004/ Accepted 11 June 2004

Antimicrobial susceptibility testing was performed on 48 isolates of Helicobacter pylori recovered from Egyptian children undergoing routine endoscopies. The isolates were universally highly resistant to metronidazole, but resistance to other tested antimicrobial agents was rare (4% for clarithromycin, erythromycin, and azithromycin resistance versus 2% for ciprofloxacin and ampicillin resistance). Use of metronidazole for the treatment of H. pylori in Egypt should be avoided.

* Corresponding author. Present address: Harbor-UCLA Medical Center, 1124 W. Carson St., Torrance, CA 90502. Phone: (310) 781-3636. Fax: (310) 972-2962. E-mail: rfrenck{at}uclacur.labiomed.org.

Journal of Clinical Microbiology, October 2004, p. 4832-4834, Vol. 42, No. 10
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.10.4832-4834.2004




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