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Antigen Assay with the Potential To Aid in Diagnosis of Blastomycosis

MiraVista Diagnostics/MiraBella Technologies, Indianapolis, Indiana

Received 27 April 2004/ Returned for modification 10 June 2004/ Accepted 23 June 2004

We report results of an immunoassay for Blastomyces dermatitidis antigenuria. Sensitivity was 92.9%, and specificity was 79.3%. Cross-reactions occurred in 96.3% of patients with histoplasmosis, 100% of patients with paracoccidioidomycosis, 70% of patients with penicilliosis marneffei, 2.9% of patients with cryptococcosis, and 1.1% of patients with aspergillosis. Reproducibility was 96.3%. These findings support a potential role for antigen testing in blastomycosis.

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