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Journal of Clinical Microbiology, October 2004, p. 4873-4875, Vol. 42, No. 10
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.10.4873-4875.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Antigen Assay with the Potential To Aid in Diagnosis of Blastomycosis

Michelle Durkin,* John Witt, Ann LeMonte, Blair Wheat, and Patricia Connolly

MiraVista Diagnostics/MiraBella Technologies, Indianapolis, Indiana

Received 27 April 2004/ Returned for modification 10 June 2004/ Accepted 23 June 2004

We report results of an immunoassay for Blastomyces dermatitidis antigenuria. Sensitivity was 92.9%, and specificity was 79.3%. Cross-reactions occurred in 96.3% of patients with histoplasmosis, 100% of patients with paracoccidioidomycosis, 70% of patients with penicilliosis marneffei, 2.9% of patients with cryptococcosis, and 1.1% of patients with aspergillosis. Reproducibility was 96.3%. These findings support a potential role for antigen testing in blastomycosis.

* Corresponding author. Mailing address: MiraVista Diagnostics/MiraBella Technologies, 4444 Decatur Blvd., Indianapolis, IN 46241. Phone: (317) 856-2681. Fax: (317) 856-3685. E-mail: mdurkin{at}miravistalabs.com.

Journal of Clinical Microbiology, October 2004, p. 4873-4875, Vol. 42, No. 10
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.10.4873-4875.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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