This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yazdankhah, S. P.
Right arrow Articles by Maiden, M. C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yazdankhah, S. P.
Right arrow Articles by Maiden, M. C. J.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, November 2004, p. 5146-5153, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5146-5153.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Distribution of Serogroups and Genotypes among Disease-Associated and Carried Isolates of Neisseria meningitidis from the Czech Republic, Greece, and Norway

Siamak P. Yazdankhah,1 Paula Kriz,2 Georgina Tzanakaki,3 Jenny Kremastinou,3 Jitka Kalmusova,2 Martin Musilek,2 Torill Alvestad,1 Keith A. Jolley,4 Daniel J. Wilson,4 Noel D. McCarthy,4 Dominique A. Caugant,1,5* and Martin C. J. Maiden4

Department of Airborne Infections, Division of Infectious Disease Control, Norwegian Institute of Public Health,1 Institute of Oral Biology, University of Oslo, Oslo, Norway,5 National Reference Laboratory for Meningococcal Infections, National Institute of Public Health, Prague, Czech Republic,2 Meningococcal Reference Laboratory, National School of Public Health, Athens, Greece,3 Department of Zoology, University of Oxford, Oxford, United Kingdom4

Received 1 June 2004/ Returned for modification 19 July 2004/ Accepted 9 August 2004

The distribution of serogroups and multilocus sequence types (STs) in collections of disease-associated and carried meningococci from the period 1991 to 2000 in three European countries (the Czech Republic, Greece, and Norway) was investigated. A total of 314 patient isolates and 353 isolates from asymptomatic carriers were characterized. The frequency distributions of serogroups and clone complexes differed among countries and between disease and carrier isolate collections. Highly significant differentiation was seen at each housekeeping locus. A marked positive association of serogroup C with disease was evidenced. The ST-11 complex was strongly positively associated with disease; associations for other clone complexes were weaker. The genetic diversity of the clone complexes differed. A single ST dominated the ST-11 clone complex, while the ST-41/44 complex exhibited greater levels of diversity. These data robustly demonstrated differences in the distribution of meningococcal genotypes in disease and carrier isolates and among countries. Further, they indicated that differences in genotype diversity and pathogenicity exist between meningococcal clone complexes.

* Corresponding author. Mailing address: Department of Airborne Infections, Division of Infectious Disease Control, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, NO-0403 Oslo, Norway. Phone: 47 22 04 23 11. Fax: 47 22 04 25 18. E-mail: dominique.caugant{at}fhi.no.

Journal of Clinical Microbiology, November 2004, p. 5146-5153, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5146-5153.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Didelot, X., Urwin, R., Maiden, M. C. J., Falush, D. (2009). Genealogical typing of Neisseria meningitidis. Microbiology 155: 3176-3186 [Abstract] [Full Text]  
  • Rameix-Welti, M.-A., Zarantonelli, M. L., Giorgini, D., Ruckly, C., Marasescu, M., van der Werf, S., Alonso, J.-M., Naffakh, N., Taha, M.-K. (2009). Influenza A Virus Neuraminidase Enhances Meningococcal Adhesion to Epithelial Cells through Interaction with Sialic Acid-Containing Meningococcal Capsules. Infect. Immun. 77: 3588-3595 [Abstract] [Full Text]  
  • Whitney, A. M., Coulson, G. B., von Gottberg, A., Block, C., Keller, N., Mayer, L. W., Messonnier, N. E., Klugman, K. P. (2009). Genotypic Comparison of Invasive Neisseria meningitidis Serogroup Y Isolates from the United States, South Africa, and Israel, Isolated from 1999 through 2002. J. Clin. Microbiol. 47: 2787-2793 [Abstract] [Full Text]  
  • Hossain, M. A., Ahmed, D., Ahmed, T., Islam, N., Breiman, R. F. (2009). Increasing Isolations of Neisseria meningitides Serogroup A from Blood and Cerebrospinal Fluid in Dhaka, Bangladesh, 1999-2006. Am J Trop Med Hyg 80: 615-618 [Abstract] [Full Text]  
  • Bergfeld, A. K., Claus, H., Lorenzen, N. K., Spielmann, F., Vogel, U., Muhlenhoff, M. (2009). The Polysialic Acid-specific O-Acetyltransferase OatC from Neisseria meningitidis Serogroup C Evolved Apart from Other Bacterial Sialate O-Acetyltransferases. J. Biol. Chem. 284: 6-16 [Abstract] [Full Text]  
  • Buckee, C. O., Jolley, K. A., Recker, M., Penman, B., Kriz, P., Gupta, S., Maiden, M. C. J. (2008). Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidis. Proc. Natl. Acad. Sci. USA 105: 15082-15087 [Abstract] [Full Text]  
  • Russell, J. E., Urwin, R., Gray, S. J., Fox, A. J., Feavers, I. M., Maiden, M. C. J. (2008). Molecular epidemiology of meningococcal disease in England and Wales 1975-1995, before the introduction of serogroup C conjugate vaccines. Microbiology 154: 1170-1177 [Abstract] [Full Text]  
  • Schoen, C., Blom, J., Claus, H., Schramm-Gluck, A., Brandt, P., Muller, T., Goesmann, A., Joseph, B., Konietzny, S., Kurzai, O., Schmitt, C., Friedrich, T., Linke, B., Vogel, U., Frosch, M. (2008). Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis. Proc. Natl. Acad. Sci. USA 105: 3473-3478 [Abstract] [Full Text]  
  • Lipsitch, M., O'Hagan, J. J (2007). Patterns of antigenic diversity and the mechanisms that maintain them. J R Soc Interface 4: 787-802 [Abstract] [Full Text]  
  • Pace, D., Pollard, A. J (2007). Meningococcal A, C, Y and W-135 polysaccharide-protein conjugate vaccines. Arch. Dis. Child. 92: 909-915 [Abstract] [Full Text]  
  • Claus, H., Elias, J., Meinhardt, C., Frosch, M., Vogel, U. (2007). Deletion of the Meningococcal fetA Gene Used for Antigen Sequence Typing of Invasive and Commensal Isolates from Germany: Frequencies and Mechanisms. J. Clin. Microbiol. 45: 2960-2964 [Abstract] [Full Text]  
  • Taha, M.-K., Vazquez, J. A., Hong, E., Bennett, D. E., Bertrand, S., Bukovski, S., Cafferkey, M. T., Carion, F., Christensen, J. J., Diggle, M., Edwards, G., Enriquez, R., Fazio, C., Frosch, M., Heuberger, S., Hoffmann, S., Jolley, K. A., Kadlubowski, M., Kechrid, A., Kesanopoulos, K., Kriz, P., Lambertsen, L., Levenet, I., Musilek, M., Paragi, M., Saguer, A., Skoczynska, A., Stefanelli, P., Thulin, S., Tzanakaki, G., Unemo, M., Vogel, U., Zarantonelli, M. L. (2007). Target Gene Sequencing To Characterize the Penicillin G Susceptibility of Neisseria meningitidis. Antimicrob. Agents Chemother. 51: 2784-2792 [Abstract] [Full Text]  
  • Tsang, R. S. W., Henderson, A. M., Cameron, M. L., Tyler, S. D., Tyson, S., Law, D. K. S., Stoltz, J., Zollinger, W. D. (2007). Genetic and Antigenic Analysis of Invasive Serogroup Y Neisseria meningitidis Isolates Collected from 1999 to 2003 in Canada. J. Clin. Microbiol. 45: 1753-1758 [Abstract] [Full Text]  
  • Callaghan, M. J., Jolley, K. A., Maiden, M. C. J. (2006). Opacity-Associated Adhesin Repertoire in Hyperinvasive Neisseria meningitidis. Infect. Immun. 74: 5085-5094 [Abstract] [Full Text]  
  • Schouls, L. M., van der Ende, A., Damen, M., van de Pol, I. (2006). Multiple-Locus Variable-Number Tandem Repeat Analysis of Neisseria meningitidis Yields Groupings Similar to Those Obtained by Multilocus Sequence Typing. J. Clin. Microbiol. 44: 1509-1518 [Abstract] [Full Text]  
  • Bennett, D. E., Cafferkey, M. T. (2006). Consecutive Use of Two Multiplex PCR-Based Assays for Simultaneous Identification and Determination of Capsular Status of Nine Common Neisseria meningitidis Serogroups Associated with Invasive Disease.. J. Clin. Microbiol. 44: 1127-1131 [Abstract] [Full Text]  
  • Birtles, A., Hardy, K., Gray, S. J., Handford, S., Kaczmarski, E. B., Edwards-Jones, V., Fox, A. J. (2005). Multilocus Sequence Typing of Neisseria meningitidis Directly from Clinical Samples and Application of the Method to the Investigation of Meningococcal Disease Case Clusters. J. Clin. Microbiol. 43: 6007-6014 [Abstract] [Full Text]  
  • Yazdankhah, S. P., Kesanopoulos, K., Tzanakaki, G., Kremastinou, J., Caugant, D. A. (2005). Variable-Number Tandem Repeat Analysis of Meningococcal Isolates Belonging to the Sequence Type 162 Complex. J. Clin. Microbiol. 43: 4865-4867 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»