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Journal of Clinical Microbiology, November 2004, p. 5337-5340, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5337-5340.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Complexity of Klebsiella pneumoniae Isolates Resistant to Both Cephamycins and Extended-Spectrum Cephalosporins at a Teaching Hospital in Taiwan

Jing-Jou Yan,1 Wen-Chien Ko,2 Hsiu-Mei Wu,3 Shu-Huei Tsai,1 Chin-Luan Chuang,1 and Jiunn-Jong Wu3*

Department of Pathology,1 Internal Medicine,2 Medical Technology, College of Medicine, National Cheng Kung University, Tainan, Taiwan3

Received 3 March 2004/ Returned for modification 13 July 2004/ Accepted 30 July 2004

Among 99 clinical Klebsiella pneumoniae isolates resistant to cefoxitin and extended-spectrum cephalosporins, coexistence of AmpC (DHA-1, CMY-2, or CMY-8) and extended-spectrum ß-lactamases (CTX-M and/or SHV) was detected in a total of 35. The remainder produced AmpC (n = 42), extended-spectrum ß-lactamases (n = 9), metallo-ß-lactamases (n = 2), or none of these enzymes (n = 11). Phenotypic characteristics of these isolates were demonstrated.

* Corresponding author. Mailing address: Department of Medical Technology, College of Medicine, National Cheng Kung University, No. 1 University Rd., Tainan, Taiwan 70101. Phone: 886-6-2353535 ext. 5775. Fax: 886-6-2363956. E-mail: jjwu{at}mail.ncku.edu.tw.

Journal of Clinical Microbiology, November 2004, p. 5337-5340, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5337-5340.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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