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Journal of Clinical Microbiology, November 2004, p. 5357-5361, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5357-5361.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Fibronectin-Binding Protein Gene Recombination and Horizontal Transfer between Group A and G Streptococci

Rebecca J. Towers,1,2,3 Daniel Gal,1,2 David McMillan,4 Kadaba S. Sriprakash,4 Bart J. Currie,1,2 Mark J. Walker,3 Gursharan S. Chhatwal,5 and Peter K. Fagan1,2,6*

Menzies School of Health Research,1 Cooperative Research Centre for Aboriginal Health,6 Institute of Advanced Studies, Charles Darwin University, Darwin, Northern Territory,2 Department of Biological Sciences, University of Wollongong, Wollongong, New South Wales,3 Queensland Institute of Medical Research, Brisbane, Queensland, Australia,4 German National Research Centre for Biotechnology, Braunschweig, Germany5

Received 20 April 2004/ Returned for modification 8 June 2004/ Accepted 30 July 2004

We report evidence of interspecies gene transfer between the important virulence factor genes sfbI and gfbA. Because the identified group G streptococcus gfbA types possess DNA cassettes that can be identified in a number of group A streptococcus strains, it appears that homologous recombination is occurring between these species.

* Corresponding author. Mailing address: Division of Infectious Disease, Menzies School of Health Research, P.O. Box 41096, Casuarina, Northern Territory 0811, Australia. Phone: 61-8-89227793. Fax: 61-8-89275187. E-mail: peterf{at}menzies.edu.au.

Journal of Clinical Microbiology, November 2004, p. 5357-5361, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5357-5361.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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