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Journal of Clinical Microbiology, November 2004, p. 5400-5402, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5400-5402.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Differentiation of Rhizomucor Species on the Basis of Their Different Sensitivities to Lovastatin

Gyöngyi Lukács,1 Tamás Papp,2* Ildikó Nyilasi,1 Erzsébet Nagy,2 and Csaba Vágvölgyi1

HAS-USZ Microbiology Research Group,2 Department of Microbiology, University of Szeged, Szeged, Hungary1

Received 10 March 2004/ Returned for modification 4 May 2004/ Accepted 14 July 2004

The opportunistic pathogens Rhizomucor pusillus and Rhizomucor miehei may be agents of frequently fatal mycotic diseases. In the present study, the susceptibilities of 27 clinical and environmental isolates of R. miehei and R. pusillus to lovastatin under different culturing conditions were investigated. Most of the R. miehei strains grew at lovastatin concentrations as high as 64 to 128 µg/ml. In contrast, the inhibitory effect of lovastatin on all of the R. pusillus strains was evident at lovastatin concentrations as low as 1 to 2 µg/ml. A simple and reliable method for species-level differentiation, based on the significantly higher sensitivity of R. pusillus to lovastatin than that of R. miehei, was elaborated. According this, on malt extract agar containing 6 µg of lovastatin/ml, R. pusillus is not able to produce colonies, while R. miehei will form compact colonies.

* Corresponding author. Mailing address: Department of Microbiology, Faculty of Sciences, University of Szeged, P.O. Box 533, H-6701, Szeged, Hungary. Phone: (36) 62 544516. Fax: (36) 62 544823. E-mail: pappt{at}bio.u-szeged.hu.

Journal of Clinical Microbiology, November 2004, p. 5400-5402, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5400-5402.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chamilos, G., Lewis, R. E., Kontoyiannis, D. P. (2006). Lovastatin Has Significant Activity against Zygomycetes and Interacts Synergistically with Voriconazole. Antimicrob. Agents Chemother. 50: 96-103 [Abstract] [Full Text]  
  • Iwen, P. C., Freifeld, A. G., Sigler, L., Tarantolo, S. R. (2005). Molecular Identification of Rhizomucor pusillus as a Cause of Sinus-Orbital Zygomycosis in a Patient with Acute Myelogenous Leukemia. J. Clin. Microbiol. 43: 5819-5821 [Abstract] [Full Text]  


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