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Journal of Clinical Microbiology, November 2004, p. 5424-5426, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5424-5426.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Genetic Confirmation of Quinine-Resistant Plasmodium falciparum Malaria Followed by Postmalaria Neurological Syndrome in a Traveler from Mozambique

Fabrizio Palmieri,1 Nicola Petrosillo,1* Maria Grazia Paglia,1 Aristide Conte,1 Delia Goletti,1 Leopoldo Paolo Pucillo,1 Michela Menegon,2 Anna Sannella,2 Carlo Severini,2 and Giancarlo Majori2

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, Istituto di Ricovero e Cura a Carattere Scientifico,1 Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Rome, Italy2

Received 29 April 2004/ Returned for modification 6 June 2004/ Accepted 9 July 2004

A case of quinine-resistant Plasmodium falciparum malaria, followed by a postmalaria neurological syndrome and a recurrence episode, is described. Genetic characterization of the P. falciparum isolate obtained by analysis of msp1 and msp2 amplicons revealed the coexistence of two genotypes causing the first malaria episode and the presence of a unique isolate responsible for the recurrence.

* Corresponding author. Mailing address: Istituto Nazionale per le Malattie Infettive "L. Spallanzani" IRCCS, II Divisione, Via Portuense 292, 00149 Rome, Italy. Phone: 39-0655170432. Fax: 39-0655170486. E-mail: petrosillo{at}inmi.it.

Journal of Clinical Microbiology, November 2004, p. 5424-5426, Vol. 42, No. 11
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.11.5424-5426.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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