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Journal of Clinical Microbiology, December 2004, p. 5477-5483, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5477-5483.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Isolates of Burkholderia pseudomallei from Northern Australia Are Distinct by Multilocus Sequence Typing, but Strain Types Do Not Correlate with Clinical Presentation

Allen C. Cheng,1,2 Daniel Godoy,3 Mark Mayo,1 Daniel Gal,1 Brian G. Spratt,3 and Bart J. Currie1,2*

Menzies School of Health Research, Charles Darwin University,1 Northern Territory Clinical School, Flinders University, Darwin, Australia,2 Department of Infectious Diseases Epidemiology, Faculty of Medicine, Imperial College London, St. Mary's Hospital, London, United Kingdom3

Received 10 June 2004/ Returned for modification 24 August 2004/ Accepted 8 September 2004

Melioidosis is the disease caused by the saprophytic organism Burkholderia pseudomallei. Previous studies have suggested some strain tropism and differential virulence. In this study, we defined strains by multilocus sequence typing (MLST) of isolates taken from the Top End of Australia's Northern Territory and compared the results with those of other strains typed worldwide. We specifically sought clinical and geographical correlates of strain types. Among 87 Australian isolates, 48 sequence types were defined. None of the sequence types in this study has been found elsewhere in the world. Strains were distributed widely throughout the region, and the different presentations of disease, including neurological and prostatic infection, were associated with many different strains. There was excellent congruence between pulsed-field gel electrophoresis and MLST, and the two typing methods had a similar level of strain discrimination. The work suggests that host and environmental factors may be more important in determining disease presentation than infecting strain type. It is possible that the distinct but diverse strain types found in this study reflect Australia's geographical isolation over many millions of years.

* Corresponding author. Mailing address: Menzies School of Health Research, P.O. Box 41096, Casuarina NT 0811, Darwin, Australia. Phone: 61 8 8922 8196. Fax: 61 8 8927 5187. E-mail: bart{at}menzies.edu.au.

Journal of Clinical Microbiology, December 2004, p. 5477-5483, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5477-5483.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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