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Journal of Clinical Microbiology, December 2004, p. 5537-5541, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5537-5541.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Burkholderia cepacia Is Associated with Pulmonary Hypertension and Increased Mortality among Cystic Fibrosis Patients

Brigitte Fauroux,^1* Nicholas Hart,^1,2 Samira Belfar,¹ Michèle Boulé,¹ Isabelle Tillous-Borde,³ Damien Bonnet,⁴ Edouard Bingen,⁵ and Annick Clément¹

Paediatric Pulmonary Department and Research Unit INSERM E 213, Armand Trousseau Hospital,¹ Paediatric Cardiology, Armand Trousseau Hospital,³ Pediatric Cardiology Department, Necker Enfants Malades Hospital,⁴ Bacteriology Laboratory, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France,⁵ Respiratory Muscle Laboratory, Royal Brompton Hospital, London, United Kingdom²

Received 2 April 2004/ Returned for modification 8 June 2004/ Accepted 17 August 2004

The aim of the study was to evaluate the impact of Burkholderia cepacia on cardiovascular status and mortality in cystic fibrosis. Seven patients infected with B. cepacia were matched with 31 patients not infected with this organism for gender, age, height, weight, genotype, and percent predicted forced expiratory volume in one second, partial arterial oxygen pressure, and pancreatic sufficiency status. The pulmonary artery systolic pressure, as assessed by transthoracic echocardiography, was significantly higher in patients infected with B. cepacia (61.3 ± 17.2 mm Hg) than in controls (37.3 ± 13.9 mm Hg; P = 0.02), and the mean acceleration time was significantly lower (77 ± 33 ms versus 108 ± 25 ms; P = 0.02). The 6-month mortality was significantly higher in patients infected with B. cepacia (57% versus 16%; P = 0.02). Six of the seven patients infected with B. cepacia harbored the same ribotype (genomovar II, B. multivorans). Pulmonary hypertension was significantly more frequent in patients infected by B. cepacia and could contribute to the increased mortality rate.

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* Corresponding author. Mailing address: Paediatric Pulmonary Department and INSERM E 213, Armand Trousseau Hospital, 28 avenue du Docteur Arnold Netter, 75012 Paris, France. Fax: 33 (0) 1-44-73-67-18. Phone: 33 (0) 1-44-73-64-71. E-mail: brigitte.fauroux{at}trs.ap-hop-paris.fr.

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Journal of Clinical Microbiology, December 2004, p. 5537-5541, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5537-5541.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

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