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Journal of Clinical Microbiology, December 2004, p. 5846-5848, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5846-5848.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Comparison of Antifungal Susceptibilities to Fluconazole and Voriconazole of Oral Candida glabrata Isolates from Head and Neck Radiation Patients

A. K. Burn,1* A. W. Fothergill,2,3 W. R. Kirkpatrick,4 B. J. Coco,4 T. F. Patterson,2,4 D. I. McCarthy,2,3 M. G. Rinaldi,2,3 and S. W. Redding1,2

Departments of General Dentistry,1 Pathology,3 Medicine, University of Texas Health Science Center San Antonio,4 South Texas Veterans Healthcare System, San Antonio, Texas2

Received 20 May 2004/ Returned for modification 23 June 2004/ Accepted 2 August 2004

The antifungal susceptibilities of 79 oral Candida glabrata isolates to fluconazole and voriconazole were compared. The MICs at which 90% of the isolates tested were inhibited were 1 µg of voriconazole/ml and 32 µg of fluconazole/ml. Oral C. glabrata isolates for which the fluconazole MICs are elevated are commonly those for which the voriconazole MICs are elevated, but these increases may be transient for voriconazole, as they are for fluconazole.

* Corresponding author. Mailing address: Department of General Dentistry, University of Texas Health Science Center San Antonio, San Antonio, TX 78229. Phone: (210) 535-1740. Fax: (210) 567-3662. E-mail: burn{at}uthscsa.edu.

Journal of Clinical Microbiology, December 2004, p. 5846-5848, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5846-5848.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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